Streptococcus oralis is an alpha-hemolytic, Gram-positive bacterium that belongs to the viridans group streptococci (VGS). Although it is a common component of the normal oral flora, its role in extraoral infections is increasingly recognized. Infections attributed to S. oralis include endocarditis, meningitis, and urinary tract infections (UTIs). Traditionally, this organism was regarded as a contaminant when isolated from UTIs. However, in this study, we report a rare case of S. oralis causing a UTI in an 83-year-old male patient with a history of recurrent UTIs. Genomic characterization was performed using both short-read and long-read sequencing technologies. The analysis revealed various virulence factors and antimicrobial resistance determinants. Notably, antimicrobial susceptibility testing showed resistance to cefepime and ceftriaxone, an uncommon finding in S. oralis. Several virulence factors were identified, including nanA, ribX, speA, scpB, and lytB, which may contribute to the organism’s ability to colonize, cause infection, and evade the host immune response. Phylogenetic analysis demonstrated close sequence similarity to S. oralis subsp. oralis and S. oralis subsp. dentisani. These findings highlight the potential of S. oralis to cause serious infections beyond the oral cavity and reveal the importance of comprehensive molecular characterization to better understand its virulence and resistance mechanisms.