Cultural responsiveness is a practice designed to achieve high-quality, equitable and culturally safe health care and health outcomes. Community leadership and partnership, particularly Indigenous, are critical in this approach. This poster presentation will illustrate how a culturally responsive governance framework has been successfully applied in an Aotearoa New Zealand project. The project- Rapua te mea ngaro ka tau (Rapua)- is facilitating a Group A Streptococcus (Strep A) vaccine development. From its inception to its completion, Rapua has established Indigenous and Community Governance groups. These groups have provided cultural Governance at all levels from leadership to study recruitment and sample collection and storage. This oversight has ensured that Indigenous participation, leadership, rights and data sovereignty frameworks have been embedded in all aspects of the project to ensure cultural responsiveness.